Ontology highlight
ABSTRACT:
SUBMITTER: Watkins S
PROVIDER: S-EPMC4127490 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Nature communications 20140619
Astrocytic endfeet cover the entire cerebral vasculature and serve as exchange sites for ions, metabolites and energy substrates from the blood to the brain. They maintain endothelial tight junctions that form the blood-brain barrier (BBB) and release vasoactive molecules that regulate vascular tone. Malignant gliomas are highly invasive tumours that use the perivascular space for invasion and co-opt existing vessels as satellite tumour form. Here we use a clinically relevant mouse model of glio ...[more]