Ontology highlight
ABSTRACT:
SUBMITTER: Pei YF
PROVIDER: S-EPMC4127980 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Pei Yu-Fang YF Zhang Lei L Papasian Christopher J CJ Wang Yu-Ping YP Deng Hong-Wen HW
Human genetics 20131011 3
Individual genome-wide association (GWA) studies and their meta-analyses represent two approaches for identifying genetic loci associated with complex diseases/traits. Inconsistent findings and non-replicability between individual GWA studies and meta-analyses are commonly observed, hence posing the critical question as to how to interpret their respective results properly. In this study, we performed a series of simulation studies to investigate and compare the statistical properties of the two ...[more]