Ontology highlight
ABSTRACT:
SUBMITTER: Hemachandra LP
PROVIDER: S-EPMC4128015 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Hemachandra L P Madhubhani P LP Patel Hitisha H Chandrasena R Esala P RE Choi Jaewoo J Piyankarage Sujeewa C SC Wang Shuai S Wang Yijin Y Thayer Emily N EN Scism Robert A RA Michalsen Bradley T BT Xiong Rui R Siklos Marton I MI Bolton Judy L JL Thatcher Gregory R J GR
Cancer prevention research (Philadelphia, Pa.) 20140305 5
The risk of developing hormone-dependent cancers with long-term exposure to estrogens is attributed both to proliferative, hormonal actions at the estrogen receptor (ER) and to chemical carcinogenesis elicited by genotoxic, oxidative estrogen metabolites. Nontumorigenic MCF-10A human breast epithelial cells are classified as ER(-) and undergo estrogen-induced malignant transformation. Selective estrogen receptor modulators (SERM), in use for breast cancer chemoprevention and for postmenopausal o ...[more]