Ontology highlight
ABSTRACT:
SUBMITTER: Lu YC
PROVIDER: S-EPMC7336132 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Lu Yen-Chun YC Chu Tinyi T Hall Matthew S MS Fu Dah-Jiun DJ Shi Quanming Q Chiu Alan A An Duo D Wang Long-Hai LH Pardo Yehudah Y Southard Teresa T Danko Charles G CG Liphardt Jan J Nikitin Alexander Yu AY Wu Mingming M Fischbach Claudia C Coonrod Scott S Ma Minglin M
Biomaterials 20190626
The physical microenvironment of tumor cells plays an important role in cancer initiation and progression. Here, we present evidence that confinement - a new physical parameter that is apart from matrix stiffness - can also induce malignant transformation in mammary epithelial cells. We discovered that MCF10A cells, a benign mammary cell line that forms growth-arrested polarized acini in Matrigel, transforms into cancer-like cells within the same Matrigel material following confinement in algina ...[more]