Ontology highlight
ABSTRACT:
SUBMITTER: Dysken MW
PROVIDER: S-EPMC4128187 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Dysken Maurice W MW Guarino Peter D PD Vertrees Julia E JE Asthana Sanjay S Sano Mary M Llorente Maria M Pallaki Muralidhar M Love Susan S Schellenberg Gerard D GD McCarten J Riley JR Malphurs Julie J Prieto Susana S Chen Peijun P Loreck David J DJ Carney Sara S Trapp George G Bakshi Rajbir S RS Mintzer Jacobo E JE Heidebrink Judith L JL Vidal-Cardona Ana A Arroyo Lillian M LM Cruz Angel R AR Kowall Neil W NW Chopra Mohit P MP Craft Suzanne S Thielke Stephen S Turvey Carolyn L CL Woodman Catherine C Monnell Kimberly A KA Gordon Kimberly K Tomaska Julie J Vatassery Govind G
Alzheimer's & dementia : the journal of the Alzheimer's Association 20130411 1
<h4>Background</h4>Alzheimer's disease (AD) has been associated with both oxidative stress and excessive glutamate activity. A clinical trial was designed to compare the effectiveness of (i) alpha-tocopherol, a vitamin E antioxidant; (ii) memantine (Namenda), an N-methyl-D-aspartate antagonist; (iii) their combination; and (iv) placebo in delaying clinical progression in AD.<h4>Methods</h4>The Veterans Affairs Cooperative Studies Program initiated a multicenter, randomized, double-blind, placebo ...[more]