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Impact of apolipoprotein E genotypes on vitamin E and memantine treatment outcomes in Alzheimer's disease.


ABSTRACT: Introduction:Because apolipoprotein E (APOE) genotypes are known risk factors for Alzheimer's disease (AD), they have been measured in clinical trial participants to determine their effect on treatment outcome. Methods:We determined APOE genotypes in a subset of subjects (N = 415) who participated in a randomized controlled trial of vitamin E and memantine in 613 veterans with mild-to-moderate AD. Results:Similar to the primary study, substudy participants receiving vitamin E also had slower functional decline than those receiving placebo. Overall, there was no difference in the rate of functional decline between APOE ?4 allele carriers and noncarriers. A significant interaction was observed between treatment and the APOE genotype on AD progression: ?4 carriers declined faster than noncarriers in the vitamin E plus memantine treatment arm. Discussion:APOE genotypes may modulate AD treatment response and should be included in the design of future randomized controlled trials.

SUBMITTER: Belitskaya-Levy I 

PROVIDER: S-EPMC6118101 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Impact of apolipoprotein E genotypes on vitamin E and memantine treatment outcomes in Alzheimer's disease.

Belitskaya-Lévy Ilana I   Dysken Maurice M   Guarino Peter P   Sano Mary M   Asthana Sanjay S   Vertrees Julia E JE   Pallaki Muralidhar M   Llorente Maria M   Love Susan S   Schellenberg Gerard G  

Alzheimer's & dementia (New York, N. Y.) 20180726


<h4>Introduction</h4>Because apolipoprotein E (APOE) genotypes are known risk factors for Alzheimer's disease (AD), they have been measured in clinical trial participants to determine their effect on treatment outcome.<h4>Methods</h4>We determined APOE genotypes in a subset of subjects (N = 415) who participated in a randomized controlled trial of vitamin E and memantine in 613 veterans with mild-to-moderate AD.<h4>Results</h4>Similar to the primary study, substudy participants receiving vitamin  ...[more]

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