Ontology highlight
ABSTRACT:
SUBMITTER: Morstein J
PROVIDER: S-EPMC7920854 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Morstein Johannes J Dacheux Mélanie A MA Norman Derek D DD Shemet Andrej A Donthamsetti Prashant C PC Citir Mevlut M Frank James A JA Schultz Carsten C Isacoff Ehud Y EY Parrill Abby L AL Tigyi Gabor J GJ Trauner Dirk D
Journal of the American Chemical Society 20200605 24
Lysophosphatidic acid (LPA) is a phospholipid that acts as an extracellular signaling molecule and activates the family of lysophosphatidic acid receptors (LPA<sub>1-6</sub>). These G protein-coupled receptors (GPCRs) are broadly expressed and are particularly important in development as well as in the nervous, cardiovascular, reproductive, gastrointestinal, and pulmonary systems. Here, we report on a photoswitchable analogue of LPA, termed <b>AzoLPA</b>, which contains an azobenzene photoswitch ...[more]