Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC4128479 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Yang Yi Y Torchinsky Miriam B MB Gobert Michael M Xiong Huizhong H Xu Mo M Linehan Jonathan L JL Alonzo Francis F Ng Charles C Chen Alessandra A Lin Xiyao X Sczesnak Andrew A Liao Jia-Jun JJ Torres Victor J VJ Jenkins Marc K MK Lafaille Juan J JJ Littman Dan R DR
Nature 20140413 7503
T-helper-17 (TH17) cells have critical roles in mucosal defence and in autoimmune disease pathogenesis. They are most abundant in the small intestine lamina propria, where their presence requires colonization of mice with microbiota. Segmented filamentous bacteria (SFB) are sufficient to induce TH17 cells and to promote TH17-dependent autoimmune disease in animal models. However, the specificity of TH17 cells, the mechanism of their induction by distinct bacteria, and the means by which they fos ...[more]