Salt-responsive gut commensal modulates TH17 axis and disease.
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ABSTRACT:
SUBMITTER: Wilck N
PROVIDER: S-EPMC6070150 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Publications
Salt-responsive gut commensal modulates T<sub>H</sub>17 axis and disease.
Wilck Nicola N Matus Mariana G MG Kearney Sean M SM Olesen Scott W SW Forslund Kristoffer K Bartolomaeus Hendrik H Haase Stefanie S Mähler Anja A Balogh András A Markó Lajos L Vvedenskaya Olga O Kleiner Friedrich H FH Tsvetkov Dmitry D Klug Lars L Costea Paul I PI Sunagawa Shinichi S Maier Lisa L Rakova Natalia N Schatz Valentin V Neubert Patrick P Frätzer Christian C Krannich Alexander A Gollasch Maik M Grohme Diana A DA Côrte-Real Beatriz F BF Gerlach Roman G RG Basic Marijana M Typas Athanasios A Wu Chuan C Titze Jens M JM Jantsch Jonathan J Boschmann Michael M Dechend Ralf R Kleinewietfeld Markus M Kempa Stefan S Bork Peer P Linker Ralf A RA Alm Eric J EJ Müller Dominik N DN
Nature 20171115 7682
A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (T<sub>H</sub>17) cells, which can also contribute to hypertension. Induction of T<sub>H</sub>17 cells depends on gut microbiota; however, the effect of salt on the gut microbiome is unknown. Here we show that high salt intake affects the gut microbiome in mice, particularly by depleting Lactobacillus murinus. Consequently, trea ...[more]
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