Unknown

Dataset Information

0

Pleiotropic functions for transcription factor zscan10.

ABSTRACT: The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported by the nature of Zscan10 expression in midgestation embryos and adults suggesting a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof.

SUBMITTER: Kraus P 

PROVIDER: S-EPMC4128777 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Pleiotropic functions for transcription factor zscan10.

Kraus Petra P   V Sivakamasundari S   Yu Hong Bing HB   Xing Xing X   Lim Siew Lan SL   Adler Thure T   Pimentel Juan Antonio Aguilar JA   Becker Lore L   Bohla Alexander A   Garrett Lillian L   Hans Wolfgang W   Hölter Sabine M SM   Janas Eva E   Moreth Kristin K   Prehn Cornelia C   Puk Oliver O   Rathkolb Birgit B   Rozman Jan J   Adamski Jerzy J   Bekeredjian Raffi R   Busch Dirk H DH   Graw Jochen J   Klingenspor Martin M   Klopstock Thomas T   Neff Frauke F   Ollert Markus M   Stoeger Tobias T   Yildrim Ali Önder AÖ   Eickelberg Oliver O   Wolf Eckhard E   Wurst Wolfgang W   Fuchs Helmut H   Gailus-Durner Valérie V   de Angelis Martin Hrabě MH   Lufkin Thomas T   Stanton Lawrence W LW  

PloS one 20140811 8

The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported b  ...[more]

Similar Datasets

Transcriptomics A Congenital Anemia Dissociates the Pleiotropic Functions of Master Transcription Factor GATA1
2021-12-31 | GSE133417 | GEO
Transcriptomics A Congenital Anemia Dissociates the Pleiotropic Functions of Master Transcription Factor GATA1 [G1E_RNAseq]
2021-12-31 | GSE133403 | GEO
Transcriptomics A Congenital Anemia Dissociates the Pleiotropic Functions of Master Transcription Factor GATA1 [Patient_RNAseq]
2021-12-31 | GSE133414 | GEO
Genomics A Congenital Anemia Dissociates the Pleiotropic Functions of Master Transcription Factor GATA1 [G1E_ChIPseq]
2021-12-31 | GSE133409 | GEO
Genomics A Congenital Anemia Dissociates the Pleiotropic Functions of Master Transcription Factor GATA1 [G1E_ATACseq]
2021-12-31 | GSE133404 | GEO
Transcriptomics A Congenital Anemia Dissociates the Pleiotropic Functions of Master Transcription Factor GATA1 [Beta-estradiol_RNAseq]
2021-12-31 | GSE133415 | GEO
Unknown Elucidating the transactivation domain of the pleiotropic transcription factor Myrf.
| S-EPMC6117317 | biostudies-literature
Unknown Two Novel AP2/EREBP Transcription Factor Genes TaPARG Have Pleiotropic Functions on Plant Architecture and Yield-Related Traits in Common Wheat.
| S-EPMC4977303 | biostudies-literature
Genomics A Congenital Anemia Dissociates the Pleiotropic Functions of Master Transcription Factor GATA1 [Patient Cut&Run]
2021-12-31 | GSE155253 | GEO
Genomics A Congenital Anemia Dissociates the Pleiotropic Functions of Master Transcription Factor GATA1 [Patient scATAC-seq]
2021-12-31 | GSE155255 | GEO