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Pleiotropic functions for transcription factor zscan10.

ABSTRACT: The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported by the nature of Zscan10 expression in midgestation embryos and adults suggesting a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof.

SUBMITTER: Kraus P 

PROVIDER: S-EPMC4128777 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Pleiotropic functions for transcription factor zscan10.

Kraus Petra P   V Sivakamasundari S   Yu Hong Bing HB   Xing Xing X   Lim Siew Lan SL   Adler Thure T   Pimentel Juan Antonio Aguilar JA   Becker Lore L   Bohla Alexander A   Garrett Lillian L   Hans Wolfgang W   Hölter Sabine M SM   Janas Eva E   Moreth Kristin K   Prehn Cornelia C   Puk Oliver O   Rathkolb Birgit B   Rozman Jan J   Adamski Jerzy J   Bekeredjian Raffi R   Busch Dirk H DH   Graw Jochen J   Klingenspor Martin M   Klopstock Thomas T   Neff Frauke F   Ollert Markus M   Stoeger Tobias T   Yildrim Ali Önder AÖ   Eickelberg Oliver O   Wolf Eckhard E   Wurst Wolfgang W   Fuchs Helmut H   Gailus-Durner Valérie V   de Angelis Martin Hrabě MH   Lufkin Thomas T   Stanton Lawrence W LW  

PloS one 20140811 8

The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported b  ...[more]

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