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7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds.

ABSTRACT: 7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones are a recently described group of spirocyclic butenolides that can be generated rapidly and as a single diastereomer through a cascade process between ?-hydroxybutenolides and aromatic aldehydes. The following outlines our findings that these spirocycles are potently cytotoxic and have a dramatic structure-function profile that provides excellent insight into the structural features required for this potency.

SUBMITTER: D'Erasmo MP 

PROVIDER: S-EPMC4129445 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds.

D'Erasmo Michael P MP   Smith William B WB   Munoz Alberto A   Mohandas Poornima P   Au Andrew S AS   Marineau Jason J JJ   Quadri Luis E N LE   Bradner James E JE   Murelli Ryan P RP  

Bioorganic & medicinal chemistry letters 20140612 16

7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones are a recently described group of spirocyclic butenolides that can be generated rapidly and as a single diastereomer through a cascade process between γ-hydroxybutenolides and aromatic aldehydes. The following outlines our findings that these spirocycles are potently cytotoxic and have a dramatic structure-function profile that provides excellent insight into the structural features required for this potency. ...[more]

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