Ontology highlight
ABSTRACT:
SUBMITTER: Lyabin DN
PROVIDER: S-EPMC4130533 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Lyabin Dmitry N DN Doronin Alexander N AN Eliseeva Irina A IA Guens Gelena P GP Kulakovskiy Ivan V IV Ovchinnikov Lev P LP
PloS one 20140812 8
The multifunctional eukaryotic protein YB-1 (Y-box binding protein 1) plays a role in DNA reparation, transcription regulation, splicing, and mRNA translation, thereby participating in many crucial events in cells. Its effect is dependent mostly on its amount, and hence, on regulation of its synthesis. Published data on regulation of synthesis of YB-1 mediated by its mRNA 5' UTR, and specifically on the 5' UTR length and the presence of TOP-like motifs in this region, are contradictory. Here we ...[more]