Ontology highlight
ABSTRACT:
SUBMITTER: Zhao XB
PROVIDER: S-EPMC4130764 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20140627 16
A series of novel 7-(N-substituted-methyl)-camptothecin derivatives was designed, synthesized, and evaluated for in vitro cytotoxicity against four human tumor cell lines, A-549, MDA-MB-231, KB, and KBvin. All of the derivatives showed promising in vitro cytotoxic activity against the tested tumor cell lines, with IC50 values ranging from 0.0023 to 1.11 μM, and were as or more potent than topotecan. Compounds 9d, 9e, and 9r exhibited the highest antiproliferative activity among all prepared deri ...[more]