Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC4130997 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Li Yonghong Y Liao Wilson W Chang Monica M Schrodi Steven J SJ Bui Nam N Catanese Joseph J JJ Poon Annie A Matsunami Nori N Callis-Duffin Kristina P KP Leppert Mark F MF Bowcock Anne M AM Kwok Pui-Yan PY Krueger Gerald G GG Begovich Ann B AB
The Journal of investigative dermatology 20081016 3
Predisposition to psoriasis is known to be affected by genetic variation in HLA-C, IL12B, and IL23R, and although other psoriasis-associated variants have been identified, incontrovertible statistical evidence for these markers has not yet been obtained. To help resolve this issue, we tested 15 single-nucleotide polymorphisms (SNPs) from 7 putative psoriasis-risk genes in 1,448 psoriasis patients and 1,385 control subjects; 3 SNPs, rs597980 in ADAM33, rs6908425 in CDKAL1 and rs3789604 in PTPN22, ...[more]