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Antifungalmycin, an antifungal macrolide from Streptomyces padanus 702

ABSTRACT: Two polyene macrolide antibiotics: antifungalmycin (1) and fungichromin (2) were isolated from the culture mycelia of Streptomyces padanus 702 via bioactivity-guided fractionation using various chromatographic procedures. Their structures were elucidated on the basis of spectral analysis, and 1 is a new polyene macrolide. Compounds 1 and 2 showed significant inhibition against Gibberella zeae with EC50 values of 26.71 and 2.21 µg/mL, Fusicoccum sp. (plantain head blight) with EC50 values of 23.4 and 3.17 µg/mL, Mucor ssp. 8894 with EC50 values of 28.80 and 2.11 µg/mL, Ustilaginoidea virens with EC50 values of 26.72 and 0.21 µg/mL, respectively. This shows that the microbial secondary metabolites 1 and 2 have the potential to be developed as agricultural fungicides for use against G. zeae, Fusicoccum sp., Mucor ssp. 8894, and U. virens.

Electronic Supplementary Material

Supplementary material is available for this article at 10.1007/s13659-011-0037-1 and is accessible for authorized users.

SUBMITTER: Wang Y

PROVIDER: S-EPMC4131570 | biostudies-literature |

REPOSITORIES: biostudies-literature

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