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Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2.

ABSTRACT: Venturicidin C (1), a new 20-membered macrolide along with the known venturicidins A (2) and B (3) were isolated from the crude extract of the Appalachian bacterial strain Streptomyces sp. TS-2-2. Additionally, nine other known compounds namely nocardamine, dehydroxynocardamine, desmethylenylnocardamine, ferrioxamine E, adenosine, riboflavin, cyclo(D)-trans-4-OH-Pro-(D)-Phe, cyclo(D)-Pro-(D)-Phe and N-(2-phenylethyl)-acetamide were also isolated and identified. The structure of the new macrolide 1 was elucidated by the cumulative analyses of NMR spectroscopy and HR-MS data. Complete NMR assignments for the known venturicidins A (2) and B (3) are also provided, for the first time, in this report. Venturicidins A-C did not inhibit the proliferation of A549 lung cancer cell line but all displayed potent antifungal activity.

SUBMITTER: Shaaban KA

PROVIDER: S-EPMC3969387 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2.

Shaaban Khaled A KA Singh Shanteri S Elshahawi Sherif I SI Wang Xiachang X Ponomareva Larissa V LV Sunkara Manjula M Copley Gregory C GC Hower James C JC Morris Andrew J AJ Kharel Madan K MK Thorson Jon S JS

The Journal of antibiotics 20131113 3

Venturicidin C (1), a new 20-membered macrolide along with the known venturicidins A (2) and B (3) were isolated from the crude extract of the Appalachian bacterial strain Streptomyces sp. TS-2-2. Additionally, nine other known compounds namely nocardamine, dehydroxynocardamine, desmethylenylnocardamine, ferrioxamine E, adenosine, riboflavin, cyclo(D)-trans-4-OH-Pro-(D)-Phe, cyclo(D)-Pro-(D)-Phe and N-(2-phenylethyl)-acetamide were also isolated and identified. The structure of the new macrolide ...[more]

PMID: 24252813

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