Ontology highlight
ABSTRACT:
SUBMITTER: Stratigopoulos G
PROVIDER: S-EPMC4131684 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Stratigopoulos George G Martin Carli Jayne F JF O'Day Diana R DR Wang Liheng L Leduc Charles A CA Lanzano Patricia P Chung Wendy K WK Rosenbaum Michael M Egli Dieter D Doherty Daniel A DA Leibel Rudolph L RL
Cell metabolism 20140501 5
Common polymorphisms in the first intron of FTO are associated with increased body weight in adults. Previous studies have suggested that a CUX1-regulatory element within the implicated FTO region controls expression of FTO and the nearby ciliary gene, RPGRIP1L. Given the role of ciliary genes in energy homeostasis, we hypothesized that mice hypomorphic for Rpgrip1l would display increased adiposity. We find that Rpgrip1l⁺/⁻ mice are hyperphagic and fatter, and display diminished suppression of ...[more]