Gene-pair expression signatures reveal lineage control.
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ABSTRACT:
SUBMITTER: Heinaniemi M
PROVIDER: S-EPMC4131748 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Gene-pair expression signatures reveal lineage control.
Heinäniemi Merja M Nykter Matti M Kramer Roger R Wienecke-Baldacchino Anke A Sinkkonen Lasse L Zhou Joseph Xu JX Kreisberg Richard R Kauffman Stuart A SA Huang Sui S Shmulevich Ilya I
Nature methods 20130421 6
The distinct cell types of multicellular organisms arise owing to constraints imposed by gene regulatory networks on the collective change of gene expression across the genome, creating self-stabilizing expression states, or attractors. We curated human expression data comprising 166 cell types and 2,602 transcription-regulating genes and developed a data-driven method for identifying putative determinants of cell fate built around the concept of expression reversal of gene pairs, such as those ...[more]
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