NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound.
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ABSTRACT:
SUBMITTER: Wedlock LE
PROVIDER: S-EPMC4132055 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
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NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound.
Wedlock Louise E LE Kilburn Matt R MR Liu Rong R Shaw Jeremy A JA Berners-Price Susan J SJ Farrell Nicholas P NP
Chemical communications (Cambridge, England) 20130801 62
Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of (195)Pt and (15)N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange. ...[more]
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