Ontology highlight
ABSTRACT:
SUBMITTER: Walde S
PROVIDER: S-EPMC4132395 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Journal of cell science 20140624 Pt 16
Defects in the biogenesis of the spindle pole body (SPB), the yeast centrosome equivalent, can lead to monopolar spindles and mitotic catastrophe. The KASH domain protein Kms2 and the SUN domain protein Sad1 colocalize within the nuclear envelope at the site of SPB attachment during interphase and at the spindle poles during mitosis in Schizosaccharomyces pombe. We show that Kms2 interacts with the essential SPB components Cut12 and Pcp1 and the Polo kinase Plo1. Depletion of Kms2 delays mitotic ...[more]