Ontology highlight
ABSTRACT:
SUBMITTER: Ahmed-Belkacem A
PROVIDER: S-EPMC4132742 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Ahmed-Belkacem Abdelhakim A Guichou Jean-François JF Brillet Rozenn R Ahnou Nazim N Hernandez Eva E Pallier Coralie C Pawlotsky Jean-Michel JM
Nucleic acids research 20140722 14
The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) is a key target for antiviral intervention. The goal of this study was to identify the binding site and unravel the molecular mechanism by which natural flavonoids efficiently inhibit HCV RdRp. Screening identified the flavonol quercetagetin as the most potent inhibitor of HCV RdRp activity. Quercetagetin was found to inhibit RdRp through inhibition of RNA binding to the viral polymerase, a yet unknown antiviral mechanism. X-ray cry ...[more]