Ontology highlight
ABSTRACT:
SUBMITTER: Tessereau C
PROVIDER: S-EPMC4132748 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Tessereau Chloé C Lesecque Yann Y Monnet Nastasia N Buisson Monique M Barjhoux Laure L Léoné Mélanie M Feng Bingjian B Goldgar David E DE Sinilnikova Olga M OM Mousset Sylvain S Duret Laurent L Mazoyer Sylvie S
Nucleic acids research 20140717 14
Large tandem repeat sequences have been poorly investigated as severe technical limitations and their frequent absence from the genome reference hinder their analysis. Extensive allelotyping of this class of variation has not been possible until now and their mutational dynamics are still poorly known. In order to estimate the mutation rate of a macrosatellite, we analysed in detail the RNU2 locus, which displays at least 50 different alleles containing 5-82 copies of a 6.1 kb repeat unit. Minin ...[more]