Ontology highlight
ABSTRACT:
SUBMITTER: Ryu KA
PROVIDER: S-EPMC4132957 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20140728 31
The innate immune response is controlled, in part, by the synergistic interaction of multiple Toll-like receptors (TLRs). This multi-receptor cooperation is responsible for the potent activity of many vaccines, but few tools have been developed to understand the spatio-temporal elements of TLR synergies. In this Communication, we present photo-controlled agonists of TLR7/8. By strategically protecting the active agonist moiety based on an agonist-bound crystal structure, TLR activity is suppress ...[more]