Ontology highlight
ABSTRACT:
SUBMITTER: Lang AH
PROVIDER: S-EPMC4133049 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Lang Alex H AH Li Hu H Collins James J JJ Mehta Pankaj P
PLoS computational biology 20140814 8
A common metaphor for describing development is a rugged "epigenetic landscape" where cell fates are represented as attracting valleys resulting from a complex regulatory network. Here, we introduce a framework for explicitly constructing epigenetic landscapes that combines genomic data with techniques from spin-glass physics. Each cell fate is a dynamic attractor, yet cells can change fate in response to external signals. Our model suggests that partially reprogrammed cells are a natural conseq ...[more]