Ontology highlight
ABSTRACT:
SUBMITTER: Rossello RA
PROVIDER: S-EPMC3762186 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Rosselló Ricardo Antonio RA Chen Chun-Chun CC Dai Rui R Howard Jason T JT Hochgeschwender Ute U Jarvis Erich D ED
eLife 20130903
Cells are fundamental units of life, but little is known about evolution of cell states. Induced pluripotent stem cells (iPSCs) are once differentiated cells that have been re-programmed to an embryonic stem cell-like state, providing a powerful platform for biology and medicine. However, they have been limited to a few mammalian species. Here we found that a set of four mammalian transcription factor genes used to generate iPSCs in mouse and humans can induce a partially reprogrammed pluripoten ...[more]