Ontology highlight
ABSTRACT:
SUBMITTER: Halliez S
PROVIDER: S-EPMC4133197 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Halliez Sophie S Jaumain Emilie E Huor Alvina A Douet Jean-Yves JY Lugan Séverine S Cassard Hervé H Lacroux Caroline C Béringue Vincent V Andréoletti Olivier O Vilette Didier D
PloS one 20140814 8
Prion transmission can occur by blood transfusion in human variant Creutzfeldt-Jakob disease and in experimental animal models, including sheep. Screening of blood and its derivatives for the presence of prions became therefore a major public health issue. As infectious titer in blood is reportedly low, highly sensitive and robust methods are required to detect prions in blood and blood derived products. The objectives of this study were to compare different methods--in vitro, ex vivo and in viv ...[more]