Ontology highlight
ABSTRACT:
SUBMITTER: Brown CW
PROVIDER: S-EPMC4134131 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Brown Carl W CW Lakin Matthew R MR Horwitz Eli K EK Fanning M Leigh ML West Hannah E HE Stefanovic Darko D Graves Steven W SW
Angewandte Chemie (International ed. in English) 20140602 28
Signal propagation through enzyme cascades is a critical component of information processing in cellular systems. Although such systems have potential as biomolecular computing tools, rational design of synthetic protein networks remains infeasible. DNA strands with catalytic activity (DNAzymes) are an attractive alternative, enabling rational cascade design through predictable base-pair hybridization principles. Multi-layered DNAzyme signaling and logic cascades are now reported. Signaling betw ...[more]