Ontology highlight
ABSTRACT:
SUBMITTER: Maattanen P
PROVIDER: S-EPMC4134347 | biostudies-literature | 2013 Sep-Oct
REPOSITORIES: biostudies-literature
Prion 20130901 5
Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative disorders caused by misfolding of a cellular protein PrP(C) into an infectious conformation PrP(Sc). Previously our group demonstrated induction of PrP(Sc)-specific antibodies with a SN6b vaccine that targets regions of the protein that are exposed upon misfolding. There are concerns that these antibodies could function as templates to promote misfolding and cause disease. To evaluate the consequences of prolonged expos ...[more]