Progesterone in transient ischemic stroke: a dose-response study.

ABSTRACT: Previous studies demonstrate the neuroprotective effects of progesterone in numerous animal injury models, but a systematic dose-response study in a transient ischemic stroke model is lacking.We investigated the effects of progesterone at different doses on post-stroke brain infarction and functional deficits in middle-aged rats.Cerebral ischemia was induced in 13-month-old male Sprague-Dawley rats by right middle cerebral artery occlusion for 2 h followed by reperfusion. Rats received intraperitoneal injections of 8, 16, or 32 mg/kg of progesterone (P8, P16, P32) or vehicle at 2 h post-occlusion followed by subcutaneous injections at 6 h and every 24 h post-injury for 7 days. Functional recovery was evaluated at intervals over 22 days using motor, sensory, and cognitive tests. Infarct size was evaluated at 22 days post-stroke.Repeated-measures ANOVA showed significant group effects on grip strength, rotarod, and sensory neglect. All progesterone-treated groups had improved (p?

SUBMITTER: Yousuf S 

PROVIDER: S-EPMC4134953 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature