Ontology highlight
ABSTRACT:
SUBMITTER: Yousuf S
PROVIDER: S-EPMC4134953 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Psychopharmacology 20140422 17
<h4>Rationale</h4>Previous studies demonstrate the neuroprotective effects of progesterone in numerous animal injury models, but a systematic dose-response study in a transient ischemic stroke model is lacking.<h4>Objectives</h4>We investigated the effects of progesterone at different doses on post-stroke brain infarction and functional deficits in middle-aged rats.<h4>Methods</h4>Cerebral ischemia was induced in 13-month-old male Sprague-Dawley rats by right middle cerebral artery occlusion for ...[more]