Ontology highlight
ABSTRACT:
SUBMITTER: Mizui M
PROVIDER: S-EPMC4135016 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Mizui Masayuki M Koga Tomohiro T Lieberman Linda A LA Beltran Jessica J Yoshida Nobuya N Johnson Mark C MC Tisch Roland R Tsokos George C GC
Journal of immunology (Baltimore, Md. : 1950) 20140725 5
IL-2, a cytokine with pleiotropic effects, is critical for immune cell activation and peripheral tolerance. Although the therapeutic potential of IL-2 has been previously suggested in autoimmune diseases, the mechanisms whereby IL-2 mitigates autoimmunity and prevents organ damage remain unclear. Using an inducible recombinant adeno-associated virus vector, we investigated the effect of low systemic levels of IL-2 in lupus-prone MRL/Fas(lpr/lpr) (MRL/lpr) mice. Treatment of mice after the onset ...[more]