Ontology highlight
ABSTRACT:
SUBMITTER: Tajima M
PROVIDER: S-EPMC2373835 | biostudies-other | 2008 May
REPOSITORIES: biostudies-other
Tajima Masaki M Wakita Daiko D Noguchi Daisuke D Chamoto Kenji K Yue Zhang Z Fugo Kazunori K Ishigame Harumichi H Iwakura Yoichiro Y Kitamura Hidemitsu H Nishimura Takashi T
The Journal of experimental medicine 20080421 5
We propose a novel role for interleukin (IL) 6 in inducing rapid spontaneous proliferation (SP) of naive CD8(+) T cells, which is a crucial step in the differentiation of colitogenic CD8(+) T cells. Homeostasis of T cells is regulated by two distinct modes of cell proliferation: major histocompatibility complex/antigen-driven rapid SP and IL-7/IL-15-dependent slow homeostatic proliferation. Using our novel model of CD8(+) T cell-dependent colitis, we found that SP of naive CD8(+) T cells is esse ...[more]