Ontology highlight
ABSTRACT:
SUBMITTER: Srivastava J
PROVIDER: S-EPMC4135401 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Srivastava Jyoti J Robertson Chadia L CL Rajasekaran Devaraja D Gredler Rachel R Siddiq Ayesha A Emdad Luni L Mukhopadhyay Nitai D ND Ghosh Shobha S Hylemon Phillip B PB Gil Gregorio G Shah Khalid K Bhere Deepak D Subler Mark A MA Windle Jolene J JJ Fisher Paul B PB Sarkar Devanand D
Cancer research 20140801 16
Retinoid X receptor (RXR) regulates key cellular responses such as cell growth and development, and this regulation is frequently perturbed in various malignancies, including hepatocellular carcinoma (HCC). However, the molecule(s) that physically govern this deregulation are mostly unknown. Here, we identified RXR as an interacting partner of astrocyte-elevated gene-1 (AEG-1)/metadherin (MTDH), an oncogene upregulated in all cancers. Upon interaction, AEG-1 profoundly inhibited RXR/retinoic aci ...[more]