Ontology highlight
ABSTRACT:
SUBMITTER: de la Fuente AG
PROVIDER: S-EPMC4674280 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
The Journal of cell biology 20151201 5
The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological ...[more]