Ontology highlight
ABSTRACT:
SUBMITTER: Blessing NA
PROVIDER: S-EPMC4135596 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Blessing Natalya A NA Brockman April L AL Chadee Deborah N DN
Molecular and cellular biology 20140609 16
Mixed-lineage kinase 3 (MLK3) activates mitogen-activated protein kinase (MAPK) signaling pathways and has important functions in migration, invasion, proliferation, tumorigenesis, and apoptosis. We investigated the role of the E3 ligase carboxyl terminus of Hsc70-interacting protein (CHIP) in the regulation of MLK3 protein levels. We show that CHIP interacts with MLK3 and, together with the E2 ubiquitin-conjugating enzyme UbcH5 (UbcH5a, -b, -c, or -d), ubiquitinates MLK3 in vitro. CHIP or Hsp70 ...[more]