Ontology highlight
ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC4215236 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Zhu Xu X Zhang Ju J Sun Huiying H Jiang Cuicui C Dong Yusheng Y Shan Qiang Q Su Siyuan S Xie Yingying Y Xu Ningzhi N Lou Xiaomin X Liu Siqi S
The Journal of biological chemistry 20140915 44
Deciphering the inositol-requiring enzyme 1 (IRE1) signaling pathway is fundamentally important for understanding the unfolded protein response (UPR). The ubiquitination of proteins residing on the endoplasmic reticulum (ER) membrane has been reported to be involved in the UPR, although the mechanism has yet to be fully elucidated. Using immunoprecipitation and mass spectrometry, IRE1 was identified as a substrate of the E3 ligase CHIP (carboxyl terminus of HSC70-interacting protein) in HEK293 c ...[more]