Ontology highlight
ABSTRACT:
SUBMITTER: Egelund EF
PROVIDER: S-EPMC4136068 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Egelund Eric F EF Weiner Marc M Singh Rajendra P RP Prihoda Thomas J TJ Gelfond Jonathon A L JA Derendorf Hartmut H Mac Kenzie William R WR Peloquin Charles A CA
Antimicrobial agents and chemotherapy 20140519 8
Rifapentine is highly protein bound in blood, but the free, unbound drug is the microbiologically active fraction. In this exploratory study, we characterized the free plasma fraction of rifapentine in 41 patients with tuberculosis. We found a lower total rifapentine concentration but significantly higher free rifapentine levels in African patients of black race compared to non-Africans. These data support larger pharmacokinetic/pharmacodynamic studies to confirm these findings and assess free r ...[more]