ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice.
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ABSTRACT:
SUBMITTER: Naydenov AV
PROVIDER: S-EPMC4136499 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice.
Naydenov Alipi V AV Horne Eric A EA Cheah Christine S CS Swinney Katie K Hsu Ku-Lung KL Cao Jessica K JK Marrs William W Blankman Jacqueline L JL Tu Sarah S Cherry Allison E AE Fung Susan S Wen Andy A Li Weiwei W Saporito Michael S MS Selley Dana E DE Cravatt Benjamin F BF Oakley John C JC Stella Nephi N
Neuron 20140701 2
The serine hydrolase α/β-hydrolase domain 6 (ABHD6) hydrolyzes the most abundant endocannabinoid (eCB) in the brain, 2-arachidonoylglycerol (2-AG), and controls its availability at cannabinoid receptors. We show that ABHD6 inhibition decreases pentylenetetrazole (PTZ)-induced generalized tonic-clonic and myoclonic seizure incidence and severity. This effect is retained in Cnr1(-/-) or Cnr2(-/-) mice, but blocked by addition of a subconvulsive dose of picrotoxin, suggesting the involvement of GAB ...[more]
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