Ontology highlight
ABSTRACT:
SUBMITTER: Khalaf AI
PROVIDER: S-EPMC4136963 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Khalaf Abedawn I AI Huggan Judith K JK Suckling Colin J CJ Gibson Colin L CL Stewart Kirsten K Giordani Federica F Barrett Michael P MP Wong Pui Ee PE Barrack Keri L KL Hunter William N WN
Journal of medicinal chemistry 20140729 15
The treatment of Human African trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important; pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp., has been identified as a candidate target, and it has been shown previously that substituted pyrrolo[2,3-d]pyrimidines are inhibitors of PTR1 from Trypanosoma brucei (J. Med. Chem. 2010, 53, 221-229). In this study, 61 new pyrrolo[2,3-d]pyrimidine ...[more]