Ontology highlight
ABSTRACT:
SUBMITTER: Della Volpe S
PROVIDER: S-EPMC6466816 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Della Volpe Serena S Nasti Rita R Queirolo Michele M Unver M Yagiz MY Jumde Varsha K VK Dömling Alexander A Vasile Francesca F Potenza Donatella D Ambrosio Francesca Alessandra FA Costa Giosué G Alcaro Stefano S Zucal Chiara C Provenzani Alessandro A Di Giacomo Marcello M Rossi Daniela D Hirsch Anna K H AKH Collina Simona S
ACS medicinal chemistry letters 20190121 4
The key role of RNA-binding proteins (RBPs) in regulating post-transcriptional processes and their involvement in several pathologies (<i>i.e.</i>, cancer and neurodegeneration) have highlighted their potential as therapeutic targets. In this scenario, Embryonic Lethal Abnormal Vision (ELAV) or Hu proteins and their complexes with target mRNAs have been gaining growing attention. Compounds able to modulate the complex stability could constitute an innovative pharmacological strategy for the trea ...[more]