Ontology highlight
ABSTRACT:
SUBMITTER: Shu C
PROVIDER: S-EPMC4137375 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Shu Chutian C Ge Hu H Song Michael M Chen Jyun-Hong JH Zhou Huimin H Qi Qu Q Wang Feng F Ma Xifeng X Yang Xiaolei X Zhang Genyan G Ding Yanwei Y Zhou Dapeng D Peng Peng P Shih Cheng-Kon CK Xu Jun J Wu Frank F
ACS medicinal chemistry letters 20140616 8
We report our discovery of a novel series of potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors. Starting from a lead identified by scaffold-hopping approach, our discovery and development efforts were focused on exploring structure-activity relationships, optimizing pharmacokinetic profile, improving in vitro and in vivo efficacy, and evaluating safety profile. The selected candidate, Imigliptin, is now undergoing clinical trial. ...[more]