Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez CA
PROVIDER: S-EPMC4137479 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Fernandez C A CA Stewart E E Panetta J C JC Wilkinson M R MR Morrison A R AR Finkelman F D FD Sandlund J T JT Pui C H CH Jeha S S Relling M V MV Campbell P K PK
Cancer chemotherapy and pharmacology 20140427 6
<h4>Purpose</h4>Asparaginase is an essential component of pediatric acute lymphoblastic leukemia (ALL) therapy. However, asparaginase-induced hypersensitivity reactions can compromise its efficacy either by directly influencing the pharmacokinetics of asparaginase or by leading to a discontinuation of asparaginase treatment. Here, we report successful challenges using native Escherichia coli asparaginase after previous hypersensitivity reactions to both PEGylated E. coli asparaginase and Erwinia ...[more]