Using VAAST to Identify Disease-Associated Variants in Next-Generation Sequencing Data.
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ABSTRACT:
SUBMITTER: Kennedy B
PROVIDER: S-EPMC4137768 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Using VAAST to Identify Disease-Associated Variants in Next-Generation Sequencing Data.
Kennedy Brett B Kronenberg Zev Z Hu Hao H Moore Barry B Flygare Steven S Reese Martin G MG Jorde Lynn B LB Yandell Mark M Huff Chad C
Current protocols in human genetics 20140424
The VAAST pipeline is specifically designed to identify disease-associated alleles in next-generation sequencing data. In the protocols presented in this paper, we outline the best practices for variant prioritization using VAAST. Examples and test data are provided for case-control, small pedigree, and large pedigree analyses. These protocols will teach users the fundamentals of VAAST, VAAST 2.0, and pVAAST analyses. ...[more]
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