Dataset Information

Lipids, lipid genes, and incident age-related macular degeneration: the three continent age-related macular degeneration consortium.

ABSTRACT: To describe associations of serum lipid levels and lipid pathway genes to the incidence of age-related macular degeneration (AMD).Meta-analysis.setting: Three population-based cohorts. population: A total of 6950 participants from the Beaver Dam Eye Study (BDES), Blue Mountains Eye Study (BMES), and Rotterdam Study (RS). observation procedures: Participants were followed over 20 years and examined at 5-year intervals. Hazard ratios associated with lipid levels per standard deviation above the mean or associated with each additional risk allele for each lipid pathway gene were calculated using random-effects inverse-weighted meta-analysis models, adjusting for known AMD risk factors. main outcome measures: Incidence of AMD.The average 5-year incidences of early AMD were 8.1%, 15.1%, and 13.0% in the BDES, BMES, and RS, respectively. Substantial heterogeneity in the effect of cholesterol and lipid pathway genes on the incidence and progression of AMD was evident when the data from the 3 studies were combined in meta-analysis. After correction for multiple comparisons, we did not find a statistically significant association between any of the cholesterol measures, statin use, or serum lipid genes and any of the AMD outcomes in the meta-analysis.In a meta-analysis, there were no associations of cholesterol measures, history of statin use, or lipid pathway genes to the incidence and progression of AMD. These findings add to inconsistencies in earlier reports from our studies and others showing weak associations, no associations, or inverse associations of high-density lipoprotein cholesterol and total cholesterol with AMD.

SUBMITTER: Klein R

PROVIDER: S-EPMC4138281 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Lipids, lipid genes, and incident age-related macular degeneration: the three continent age-related macular degeneration consortium.

Klein Ronald R Myers Chelsea E CE Buitendijk Gabriëlle H S GH Rochtchina Elena E Gao Xiaoyi X de Jong Paulus T V M PT Sivakumaran Theru A TA Burlutsky George G McKean-Cowdin Roberta R Hofman Albert A Iyengar Sudha K SK Lee Kristine E KE Stricker Bruno H BH Vingerling Johannes R JR Mitchell Paul P Klein Barbara E K BE Klaver Caroline C W CC Wang Jie Jin JJ

American journal of ophthalmology 20140528 3

<h4>Purpose</h4>To describe associations of serum lipid levels and lipid pathway genes to the incidence of age-related macular degeneration (AMD).<h4>Design</h4>Meta-analysis.<h4>Methods</h4>setting: Three population-based cohorts. population: A total of 6950 participants from the Beaver Dam Eye Study (BDES), Blue Mountains Eye Study (BMES), and Rotterdam Study (RS). observation procedures: Participants were followed over 20 years and examined at 5-year intervals. Hazard ratios associated with l ...[more]

PMID: 24879949

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Project description:PurposePrediction models for age-related macular degeneration (AMD) based on case-control studies have a tendency to overestimate risks. The aim of this study is to develop a prediction model for late AMD based on data from population-based studies.DesignThree population-based studies: the Rotterdam Study (RS), the Beaver Dam Eye Study (BDES), and the Blue Mountains Eye Study (BMES) from the Three Continent AMD Consortium (3CC).ParticipantsPeople (n = 10,106) with gradable fundus photographs, genotype data, and follow-up data without late AMD at baseline.MethodsFeatures of AMD were graded on fundus photographs using the 3CC AMD severity scale. Associations with known genetic and environmental AMD risk factors were tested using Cox proportional hazard analysis. In the RS, the prediction of AMD was estimated for multivariate models by area under receiver operating characteristic curves (AUCs). The best model was validated in the BDES and BMES, and associations of variables were re-estimated in the pooled data set. Beta coefficients were used to construct a risk score, and risk of incident late AMD was calculated using Cox proportional hazard analysis. Cumulative incident risks were estimated using Kaplan-Meier product-limit analysis.Main outcome measuresIncident late AMD determined per visit during a median follow-up period of 11.1 years with a total of 4 to 5 visits.ResultsOverall, 363 participants developed incident late AMD, 3378 participants developed early AMD, and 6365 participants remained free of any AMD. The highest AUC was achieved with a model including age, sex, 26 single nucleotide polymorphisms in AMD risk genes, smoking, body mass index, and baseline AMD phenotype. The AUC of this model was 0.88 in the RS, 0.85 in the BDES and BMES at validation, and 0.87 in the pooled analysis. Individuals with low-risk scores had a hazard ratio (HR) of 0.02 (95% confidence interval [CI], 0.01-0.04) to develop late AMD, and individuals with high-risk scores had an HR of 22.0 (95% CI, 15.2-31.8). Cumulative risk of incident late AMD ranged from virtually 0 to more than 65% for those with the highest risk scores.ConclusionsOur prediction model is robust and distinguishes well between those who will develop late AMD and those who will not. Estimated risks were lower in these population-based studies than in previous case-control studies.

Dataset Information

Lipids, lipid genes, and incident age-related macular degeneration: the three continent age-related macular degeneration consortium.

Publications

Lipids, lipid genes, and incident age-related macular degeneration: the three continent age-related macular degeneration consortium.

Similar Datasets

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