Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase.

ABSTRACT: The PTH receptor is to our knowledge one of the first G protein-coupled receptor (GPCR) found to sustain cAMP signaling after internalization of the ligand-receptor complex in endosomes. This unexpected model is adding a new dimension on how we think about GPCR signaling, but its mechanism is incompletely understood. We report here that endosomal acidification mediated by the PKA action on the v-ATPase provides a negative feedback mechanism by which endosomal receptor signaling is turned off.

SUBMITTER: Gidon A 

PROVIDER: S-EPMC4138287 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature