Ontology highlight
ABSTRACT:
SUBMITTER: Daigle TL
PROVIDER: S-EPMC4138757 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20140429 10
GRK2 is a G protein-coupled receptor kinase (GRK) that is broadly expressed and is known to regulate diverse types of receptors. GRK2 null animals exhibit embryonic lethality due to a severe developmental heart defect, which has precluded the study of this kinase in the adult brain. To elucidate the specific role of GRK2 in the brain dopamine (DA) system, we used a conditional gene knockout approach to selectively delete GRK2 in DA D1 receptor (D1R)-, DA D2 receptor (D2R)-, adenosine 2A receptor ...[more]