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Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars.

ABSTRACT: Chlorin e6 conjugated gold nanostars (GNS-PEG-Ce6) are used to perform simultaneous photodynamic/plasmonic photothermal therapy (PDT/PPTT) upon single laser irradiation. The early-phase PDT effect is coordinated with the late-phase PPTT effect to obtain synergistic anticancer efficiency. The prepared GNS-PEG-Ce6 shows excellent water dispersibility, good biocompatibility, enhanced cellular uptake and remarkable anticancer efficiency upon irradiation in vivo.

SUBMITTER: Wang S 

PROVIDER: S-EPMC4138877 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars.

Wang Shouju S   Huang Peng P   Nie Liming L   Xing Ruijun R   Liu Dingbin D   Wang Zhe Z   Lin Jing J   Chen Shouhui S   Niu Gang G   Lu Guangming G   Chen Xiaoyuan X  

Advanced materials (Deerfield Beach, Fla.) 20130213 22

Chlorin e6 conjugated gold nanostars (GNS-PEG-Ce6) are used to perform simultaneous photodynamic/plasmonic photothermal therapy (PDT/PPTT) upon single laser irradiation. The early-phase PDT effect is coordinated with the late-phase PPTT effect to obtain synergistic anticancer efficiency. The prepared GNS-PEG-Ce6 shows excellent water dispersibility, good biocompatibility, enhanced cellular uptake and remarkable anticancer efficiency upon irradiation in vivo. ...[more]

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