Unknown

Dataset Information

0

Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy.


ABSTRACT: A multifunctional theranostic platform based on photosensitizer-loaded plasmonic vesicular assemblies of gold nanoparticles (GNPs) is developed for effective cancer imaging and treatment. The gold vesicles (GVs) composed of a monolayer of assembled GNPs show strong absorbance in the near-infrared (NIR) range of 650-800 nm, as a result of the plasmonic coupling effect between neighboring GNPs in the vesicular membranes. The strong NIR absorption and the capability of encapsulating photosensitizer Ce6 in GVs enable trimodality NIR fluorescence/thermal/photoacoustic imaging-guided synergistic photothermal/photodynamic therapy (PTT/PDT) with improved efficacy. The Ce6-loaded GVs (GV-Ce6) have the following characteristics: (i) high Ce6 loading efficiency (up to ~18.4 wt %; (ii) enhanced cellular uptake efficiency of Ce6; (iii) simultaneous trimodality NIR fluorescence/thermal/photoacoustic imaging; (iv) synergistic PTT/PDT treatment with improved efficacy using single wavelength continuous wave laser irradiation.

SUBMITTER: Lin J 

PROVIDER: S-EPMC3709863 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy.

Lin Jing J   Wang Shouju S   Huang Peng P   Wang Zhe Z   Chen Shouhui S   Niu Gang G   Li Wanwan W   He Jie J   Cui Daxiang D   Lu Guangming G   Chen Xiaoyuan X   Nie Zhihong Z  

ACS nano 20130530 6


A multifunctional theranostic platform based on photosensitizer-loaded plasmonic vesicular assemblies of gold nanoparticles (GNPs) is developed for effective cancer imaging and treatment. The gold vesicles (GVs) composed of a monolayer of assembled GNPs show strong absorbance in the near-infrared (NIR) range of 650-800 nm, as a result of the plasmonic coupling effect between neighboring GNPs in the vesicular membranes. The strong NIR absorption and the capability of encapsulating photosensitizer  ...[more]

Similar Datasets

| S-EPMC4138877 | biostudies-literature
| S-EPMC3915087 | biostudies-literature
| S-EPMC3645870 | biostudies-literature
| S-EPMC3900801 | biostudies-other
| S-EPMC3407577 | biostudies-literature
| S-EPMC4837698 | biostudies-literature
| S-EPMC4058316 | biostudies-literature
| S-EPMC9612258 | biostudies-literature
| S-EPMC6794780 | biostudies-literature
| S-EPMC4568826 | biostudies-literature