Ontology highlight
ABSTRACT:
SUBMITTER: Matus DQ
PROVIDER: S-EPMC4138880 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Matus David Q DQ Chang Emily E Makohon-Moore Sasha C SC Hagedorn Mary A MA Chi Qiuyi Q Sherwood David R DR
Nature communications 20140613
Large gaps in basement membrane (BM) occur during organ remodelling and cancer cell invasion. Whether dividing cells, which temporarily reduce their attachment to BM, influence these breaches is unknown. Here we analyse uterine-vulval attachment during development across 21 species of rhabditid nematodes and find that the BM gap that forms between these organs is always bounded by a non-dividing vulval cell. Through cell cycle manipulation and live cell imaging in Caenorhabditis elegans, we show ...[more]