Ontology highlight
ABSTRACT:
SUBMITTER: Mahmoud AI
PROVIDER: S-EPMC4159712 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Mahmoud Ahmed I AI Kocabas Fatih F Kocabas Fatih F Muralidhar Shalini A SA Kimura Wataru W Koura Ahmed S AS Thet Suwannee S Porrello Enzo R ER Sadek Hesham A HA
Nature 20130417 7448
The neonatal mammalian heart is capable of substantial regeneration following injury through cardiomyocyte proliferation. However, this regenerative capacity is lost by postnatal day 7 and the mechanisms of cardiomyocyte cell cycle arrest remain unclear. The homeodomain transcription factor Meis1 is required for normal cardiac development but its role in cardiomyocytes is unknown. Here we identify Meis1 as a critical regulator of the cardiomyocyte cell cycle. Meis1 deletion in mouse cardiomyocyt ...[more]