Ontology highlight
ABSTRACT:
SUBMITTER: Burns JR
PROVIDER: S-EPMC4139251 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Burns Joshua R JR Baldwin Michael R MR
The Journal of biological chemistry 20140627 32
Tetanus neurotoxin (TeNT) causes neuroparalytic disease by entering the neuronal soma to block the release of neurotransmitters. However, the mechanism by which TeNT translocates its enzymatic domain (light chain) across endosomal membranes remains unclear. We found that TeNT and a truncated protein devoid of the receptor binding domain (TeNT-LHN) associated with membranes enriched in acidic phospholipids in a pH-dependent manner. Thus, in contrast to diphtheria toxin, the formation of a membran ...[more]